Researchers in Arizona have identified a way to sensitise prostate tumours to immune checkpoint inhibitors. They were able to reduce cancer tumour growth in laboratory and animal models of prostate cancer by inhibiting the protein inhitor PIM1 kinetase in conjunction with an immune checkpoint inhibitor. PIM inhibitors are actively being tested to combat cancer and other diseases. The work may lead to a new US clinical trial.

Read the full article here.

The PRAISE-U Project, which is led by the EAU, aims to provide concrete evidence on a risk-stratified approach to the early detection of prostate cancer outside a trial setting. An article in European Urology Today explains how it is currently coordinating five population-based prostate cancer screening pilots in four different European Member States. PRAISE-U is closely working with the EUCanScreen initiative, which started last year. Within EUCanScreen, at least 10 more Member States will start population-based prostate cancer screening pilot studies.

Read the article here.

There have been key changes to the European Association of Urology Guidelines on Prostate Cancer. New evidence has been identified, collated and appraised through a structured assessment of the literature for all sections of the guidelines.

A full version of the guidelines 2025 can be found here.

At the EAU25 in Madrid last week, the presentations in the session “Early detection and diagnosis pathways in prostate cancer revisited”, covered ongoing trials seeking the best way to screen men for prostate cancer.

You can read the article here.

Patients received a prominent place at the EAU Congress this year, with representatives from patient organisations assembled at the EAU Patient Plaza. The dynamic space featured a theatre area where patient organisations could host 30-minute presentations and lively debates.

Europa Uomo organised three theatre sessions:

• Shared-decision making in urology (You can watch the session here where Erik Briers presented on the SDM survey)
• Challenges of radio-ligand therapy
• Prostate cancer screening and PRAISE-U

Europa Uomo’s Chairman, Günther Carl, also participated in a theatre session on “AI generated chatbots in Urology”.

Our Vice-Chairman, Erik Briers, gave a presentation on EUPROMS in the Roundtable ‘Prostate Cancer: Let’s talk about sex’. You can watch the session here.

One of Europa Uomo’s past chairmen, Ken Mastris (UK), received the third place prize in the category Best Patient Poster Award at EAU25. You can read the winning poster “Crucial role of patient authors in content co-creation of patient-relevant scientific data” here.

Active Surveillance Patients International (ASPI) is organising a webinar on Saturday, 29th March from 5pm on “Sorting Out Biomarkers: a guide for patients on active surveillance”. The webinar will featur Jonathan Tward, an international authority on biomarkers.

To register, click here.

Thrainn Thorvaldsson, an ASPI Board Member, has introduced the Cave Men initiative, designed to create small, supportive discussion groups for men dealing with the challenges of prostate cancer and active surveillance.

ASPI is seeking participants who are interested in joining a Cave Men group and leaders who are willing to take the lead and organise meetings. If you are interested in joining or leading a Cave Men group, please reach out Thrainn Thorvaldsson at tthorvaldsson@aspatients.org.

The 2025 EU Country Cancer Profiles report contains 29 profiles which identify strengths, challenges and specific areas of action for each of the 27 EU Member States plus Iceland and Norway, to guide investment and interventions at EU, national and regional levels under Europe’s Beating Cancer Plan.

You can also find a specific cancer profile for your own country.